WAEC 3005
304-696-5677
Biography
Dr. Shim is an associate professor in the Department of Biomedical Engineering at Marshall University. He earned Ph.D. in Biomedical Engineering at Mississippi State University. Dr. Shim did postdoctoral training in neuroscience at Boston Children’s Hospital/Harvard Medical School and cardiovascular science at Boston University School of Medicine. His research interest is centered on neurovascular interactions contributing to the mechanisms that underlie hydrocephalus of all ages. Dr. Shim teaches BME Seminar, Introduction to Biophysical Measurements, and Capstone
Ph.D. Mississippi State University, Starkville, M.S. 2006
M.S. Rensselaer Polytechnic Institute, Troy, N.Y. 2003
Cellular biomechanics; Experimental bioengineering
The NASA Research Initiation Grant (RIG), July 2023 – July 2024. Role: PI
the NASA Established Program to Stimulate Competitive Research, Grant # 80NSSC22M0027, May 2022 – July 2023. Role: PI
Hydrocephalus & Neurodegeneration
CECS Cross-disciplinary Research Facilitation Grant Program, Interdivisional Research Group Awards, Shim (PI), 1/1/20-8/31/20. Role: PI (w/ Dr. Sanghoon Lee at Computer Science, Marshall University)
Shim JW, Hyacinth HI, Gonzalez-Perez O. Editorial: Current therapeutic approaches in Alzheimer's disease: the use of a second drug with anti-amyloid-beta and beyond. Front Neurosci. 2024 Jul 8;18:1449365. doi: 10.3389/fnins.2024.1449365. PMID: 39040632; PMCID: PMC11261994. (Link)
Barrett E, Ivey G, Cunningham A, Coffman G, Pemberton T, Lee C, Patra P, Day JB, Lee PHU, Shim JW. Reduced GLP-1R availability in the caudate nucleus with Alzheimer's disease. Front Aging Neurosci. 2024 Jun 10;16:1350239. doi: 10.3389/fnagi.2024.1350239. PMID: 38915346; PMCID: PMC11194438. (Link)
Hart M, Conrad J, Barrett E, Legg K, Ivey G, Lee PHU, Yung Y, Shim JW. X-linked hydrocephalus genes: Their proximity to telomeres and high A + T content compared to Parkinson's disease. Exp Neurol. 2023 May 6:114433. doi: 10.1016/j.expneurol.2023.114433. Epub ahead of print. PMID: 37156332.Link
McKnight I, Raines R, White H, Nosoudi N, Lee C, Lee PHU, Shim JW. (2023) Mutability of druggable kinases and pro-inflammatory cytokines by their proximity to telomeres and A+T content. PLoS ONE 18(4): e0283470. Link
White H, Webb R, McKnight I, Legg K, Lee C, Lee PHU, Spicer OS and Shim JW (2022), TRPV4 mRNA is elevated in the caudate nucleus with NPH but not in Alzheimer’s disease. Front. Genet. 13:936151. doi: 10.3389/fgene.2022.936151
Raines R, McKnight I, White H, Legg K, Lee C, Li W, Lee PHU, Shim JW. Drug-Targeted Genomes: Mutability of Ion Channels and GPCRs. Biomedicines. 2022 Mar 3;10(3):594. doi: 10.3390/biomedicines10030594. PMID: 35327396; PMCID: PMC8945769.
Lucas HB, McKnight I, Raines R, Hijazi A, Hart C, Lee C, Kim DG, Li W, Lee PHU, Shim JW. Factors Associated with Mutations: Their Matching Rates to Cardiovascular and Neurological Diseases. Int J Mol Sci. 2021 May 11;22(10):5057. doi: 10.3390/ijms22105057. PMID: 34064609; PMCID: PMC8151074.
McKnight I, Hart C, Park IH, Shim JW. Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositions. Exp Neurol. 2020 Nov 3:113523. doi: 10.1016/j.expneurol.2020.113523. Epub ahead of print. PMID: 33157092.
Hochstetler AE, Smith HM, Preston DC, Reed MM, Territo PR, Shim JW, Fulkerson D, Blazer-Yost BL. TRPV4 antagonists ameliorate ventriculomegaly in a rat model of hydrocephalus. JCI Insight. 2020 Sep 17;5(18):e137646. doi: 10.1172/jci.insight.137646. PMID: 32938829; PMCID: PMC7526552.
Shim JW, Territo PR, Simpson S, Watson JC, Jiang L, Riley AA, McCarthy B, Persohn S, Fulkerson D, Blazer-Yost BL. Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation. Sci Rep. 2019 Jan 31;9(1):1069. doi: 10.1038/s41598-018-37620-5. PMID: 30705305; PMCID: PMC6355840.
Shim JW, Madsen JR. VEGF Signaling in Neurological Disorders. Int J Mol Sci. 2018 Jan 17;19(1):275. doi: 10.3390/ijms19010275. PMID: 29342116; PMCID: PMC5796221.
Walsh KR, Kuwabara JT, Shim JW, Wainford RD. Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 15;310(2):R115-24. doi: 10.1152/ajpregu.00514.2014. Epub 2015 Nov 25. PMID: 26608659; PMCID: PMC4796647.
Shim JW, Sandlund J, Hameed MQ, Blazer-Yost B, Zhou FC, Klagsbrun M, Madsen JR. Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus. Sci Rep. 2016 May 31;6:26794. doi: 10.1038/srep26794. PMID: 27243144; PMCID: PMC4886677.
Shim JW, Sandlund J, Madsen JR. VEGF: a potential target for hydrocephalus. Cell Tissue Res. 2014 Dec;358(3):667-83. doi: 10.1007/s00441-014-1978-6. Epub 2014 Aug 23. PMID: 25146955.
Shim JW, Dodge TR, Hammond MA, Wallace JM, Zhou FC, Yokota H. Physical weight loading induces expression of tryptophan hydroxylase 2 in the brain stem. PLoS One. 2014 Jan 8;9(1):e85095. doi: 10.1371/journal.pone.0085095. PMID: 24416346; PMCID: PMC3885668.
Shim JW, Sandlund J, Han CH, Hameed MQ, Connors S, Klagsbrun M, Madsen JR, Irwin N. VEGF, which is elevated in the CSF of patients with hydrocephalus, causes ventriculomegaly and ependymal changes in rats. Exp Neurol. 2013 Sep;247:703-9. doi: 10.1016/j.expneurol.2013.03.011. Epub 2013 Mar 19. PMID: 23518418.
Zhao L, Shim JW, Dodge TR, Robling AG, Yokota H. Inactivation of Lrp5 in osteocytes reduces young’s modulus and responsiveness to the mechanical loading. Bone. 2013 May;54(1):35-43. doi: 10.1016/j.bone.2013.01.033. Epub 2013 Jan 26. PMID: 23356985; PMCID: PMC3602226.